Earlier in the day, RFE/RL's Uzbek Service reported that Karimov had traveled to the city of Ferghana to make the announcement before the regional parliament.
The reasons for the personnel change were not immediately clear.
The independent Uzmetronom website reported simply that the outgoing governor, Shermat Normatov, had fallen out of presidential favor.
Ferghana and neighboring Andijon lie in the extreme eastern part of Uzbekistan, in a region that borders Kyrgyzstan and Tajikistan. Ferghana Valley spans Uzbek, Tajik, and Kyrgyz territory and is regarded by Central Asian governments as a hotbed of religious fundamentalism.
Karimov fired the head of the Andijon Region on October 13, blaming him for the popular uprising and ensuing crackdown that officially claimed 187 lives in May 2005. That dismissal appeared to signal a possible reappraisal of the official tack on the events of Andijon.
Officials at the time blamed foreign-backed religious extremists for the initial violence, although rights groups and residents have noted that social and economic woes made the region a powder keg.
Addressing Andijon lawmakers on October 13, Karimov accused Andijon Governor Saydullo Begaliev of ignoring the population's needs.
Rights groups also challenge the official account of events and accuse the government of ordering the killing of hundreds of unarmed civilians.
The United Nations and Western governments have urged Tashkent to allow independent investigators to explore the Andijon violence, but Karimov's administration has rejected the advice and courted closer ties to Moscow in response to Western pressure.
(press-service.uz, RFE/RL's Uzbek Service, uzmetronom.net)
Andijon Anniversary Conference
Violence in Andijon, Uzbekistan, on May 14, 2005 (epa)
LISTEN
Listen to the Andijon conference.Part One (70 minutes):
Real Audio Windows Media
Part Two (60 minutes):
Real Audio Windows Media
The Uzbek government's response:
Real Audio Windows Media
THE COMPLETE STORY: A dedicated webpage bringing together all of RFE/RL's coverage of the events in Andijon, Uzbekistan, in May 2005 and their continuing repercussions.
CHRONOLOGY
For an annotated timeline of the Andijon events and their repercussions, click here.